PainScience. com What works for stubborn aches, pains, and injuries? And what doesn’t? And why? PainScience com explores the surprisingly weird science of many kinds of chronic pain and injury, from fibromyalgia to runner’s knee The site is a library of a couple hundred deep-dive articles for both patients and healthcare professionals, informal but heavily referenced and constantly updated for 20 years
Cartilage regeneration with implanted chondrocytes: the evidence Stem cell therapy is a broad concept in regenerative medicine, and it is a hot hot hot topic right now Stem cell therapy is identical in spirit to the other two main regenerative therapies in musculoskeletal and pain medicine: platelet-rich plasma and cartilage regeneration
Platelet-Rich Plasma (PRP): Does It Work? - painscience. com Stem cell therapy is a broad concept in regenerative medicine, and it is a hot hot hot topic right now It’s identical in spirit to the other two main regenerative therapies in musculoskeletal and pain medicine: platelet-rich plasma and autologous chondrocyte implantation
Build it they will come: regeneration be cell homing [PainSci . . . One page on PainSci cites Lee 2010: Salamander Science and Regenerative Medicine PainSci commentary on Lee 2010: ? Build it and the cells will come This proof-of-concept study demonstrated what happens if you replace the end of a rabbit’s femur with an empty plastic “scaffolding” of exactly the same shape, and then fertilize it with transforming growth factor beta3 Cells migrate into
Robotic Mouse Massage: Is It “Regenerative” and “Anti-Inflammatory . . . The most generous possible interpretation It might be exactly what it seems to be, in principle: mechanical stimulation is “anti-inflammatory” and “regenerative” in some meaningful sense, to some degree Maybe injured muscles actually do heal faster when treated like this
PRP for arthritic knees: a science update I have long been critical of platelet-rich plasma (PRP) — injections of your own concentrated blood, still supposedly “ regenerative ” despite piles of underwhelming evidence In July I posted about an interesting new trial that was, predictably, “ a credible negative for PRP ” As always, “ negativity ” about PRP is a complaint
About PainScience. com and the science of aches, pains, and injuries Their regenerative superpower is an inspiring, profound example of what is possible in biology Regenerative biology isn’t very relevant to most aches and pains and injuries, but that may change as the (over-hyped) stem cell therapies are refined and advanced
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